In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines.

@article{Nishikawa2006InVA,
  title={In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines.},
  author={Hiroyoshi Nishikawa and Eiichi Sato and G Briones and Li-mei Chen and Mitsutoshi Matsuo and Yasuhiro Nagata and Gerd Ritter and E. P. Jaeger and Hideki Nomura and Shigeto Kondo and Isao Tawara and Takuma Kato and Hiroshi Shiku and L. John Old and Jorge E. Gal{\'a}n and Sacha Gnjatic},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 7},
  pages={
          1946-54
        }
}
Bacterial vectors may offer many advantages over other antigen delivery systems for cancer vaccines. We engineered a Salmonella typhimurium vaccine strain to deliver the NY-ESO-1 tumor antigen (S. typhimurium-NY-ESO-1) through a type III protein secretion system. The S. typhimurium-NY-ESO-1 construct elicited NY-ESO-1-specific CD8+ and CD4+ T cells from peripheral blood lymphocytes of cancer patients in vitro. Oral administration of S. typhimurium-NY-ESO-1 to mice resulted in the regression of… CONTINUE READING
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