In vivo antibacterial activity of FK041, a new orally active cephalosporin.

@article{Tawara1999InVA,
  title={In vivo antibacterial activity of FK041, a new orally active cephalosporin.},
  author={Shuichi Tawara and Kazuo Hatano and Yoshimi Wakai and Satoru Matsumoto and Yasuo Watanabe and Fumio Matsumoto and Shogo Kuwahara},
  journal={The Journal of antibiotics},
  year={1999},
  volume={52 7},
  pages={660-5}
}
The therapeutic activities of orally administered FK041 were evaluated in mouse models of systemic and local infections with a variety of bacteria and were compared with those of cefdinir (CFDN) and cefditoren pivoxil (CDTR-PI). FK041 exhibited potent therapeutic activity against lethal systemic infections induced by intraperitoneally inoculated Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae with 50% effective doses (ED50) in the range of 0.20 to 0.36 mg/kg and was more… CONTINUE READING