In vivo anti-inflammatory activity of lipoic acid derivatives in mice.

@article{Kwiecie2013InVA,
  title={In vivo anti-inflammatory activity of lipoic acid derivatives in mice.},
  author={Brunon Kwiecień and Magdalena Dudek and Anna Bilska-Wilkosz and Joanna Knutelska and Marek Bednarski and Inga Kwiecień and Małgorzata Zygmunt and Małgorzata B Iciek and Maria Sokołowska-Jeżewicz and Jacek Sapa and Lidia B Włodek},
  journal={Postepy higieny i medycyny doswiadczalnej},
  year={2013},
  volume={67},
  pages={
          331-8
        }
}
BACKGROUND In mammals lipoic acid (LA) and its reduced form dihydrolipoic acid (DHLA) function as cofactors for multienzymatic complexes catalyzing the decarboxylation of α-ketoacids. Moreover, LA is used as a drug in a variety of diseases including inflammatory diseases. The aim of the study was to examine anti-inflammatory properties of LA metabolites. MATERIAL/METHODS The present paper reports the chemical synthesis of 2,4-bismethylthio-butanoic acid (BMTBA) and tetranor-dihydrolipoic acid… CONTINUE READING
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