In vivo anomalous diffusion and weak ergodicity breaking of lipid granules.

@article{Jeon2011InVA,
  title={In vivo anomalous diffusion and weak ergodicity breaking of lipid granules.},
  author={Jae-Hyung Jeon and Vincent Tejedor and S. Burov and Eli Barkai and Christine Selhuber-Unkel and Kirstine Berg-S{\o}rensen and Lene Broeng Oddershede and Ralf Metzler},
  journal={Physical review letters},
  year={2011},
  volume={106 4},
  pages={
          048103
        }
}
Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared… 
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References

SHOWING 1-10 OF 66 REFERENCES
The Langevin Equation
The generalized Langevin equation describes processes in a mechanical system with both deterministic and random forces which have comparable magnitudes (i.e., neither the deterministic nor random
Single particle tracking and single molecule energy transfer
Preface PART I: Single-Particle Imaging and Tracking THREE DIMENSIONAL PARTICLE TRACKING IN A LASER SCANNING FLUORESCENCE MICROSCOPE Introduction Image-Based Single-Particle Tracking Methods Advanced
Editors
  • Brain Research Bulletin
  • 1986
This specification defines the Document Object Model Level 2 HTML, a platformand language-neutral interface that allows programs and scripts to dynamically access and update the content and structure
Phys. Rev. Lett
  • Phys. Rev. Lett
  • 2010
Proc. Natl. Acad. Sci. USA 107
  • Proc. Natl. Acad. Sci. USA 107
  • 2010
Phys. Rev. Lett
  • Phys. Rev. Lett
  • 2009
Phys. Rev. Lett
  • Phys. Rev. Lett
  • 2008
Biophys. J
  • Biophys. J
  • 2010
PLoS Comput
  • Biol. 6, e1000694
  • 2010
PLoS Comput. Biol
  • PLoS Comput. Biol
  • 2010
...
1
2
3
4
5
...