In vivo andin vitro evaluation of magnesium-aluminum hydroxide antacid tablets and liquid

  title={In vivo andin vitro evaluation of magnesium-aluminum hydroxide antacid tablets and liquid},
  author={C C Barnett and Charles T. Richardson},
  journal={Digestive Diseases and Sciences},
The effect of magnesium-aluminum hydroxide antacid tablets or liquid on food-stimulated gastric acidity was evaluatedin vivo in eight duodenal ulcer patients. Experiments were performed alsoin vitro. Althoughin vitro neutralizing capabilities of the two preparations were the same (28.3±0.1 mmol/liter), the duration of effect of tablets was longerin vivo. For example, at 33/4 hr after an eaten meal, mean hydrogen ion concentration with three tablets was 29.8±9.9 mmol/liter while with 15 ml… 
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