In vivo and in vitro reactions of toluene diisocyanate isomers with guinea pig hemoglobin.

@article{Day1996InVA,
  title={In vivo and in vitro reactions of toluene diisocyanate isomers with guinea pig hemoglobin.},
  author={Billy W. Day and Raymond R. Jin and Meryl H. Karol},
  journal={Chemical research in toxicology},
  year={1996},
  volume={9 3},
  pages={
          568-73
        }
}
Guinea pig hemoglobin (Hb) adducts of 2,4- and 2,6-toluene diisocyanate (2,4- and 2,6-TDI) were individually prepared, each at a Hb tetramer to diisocyanate ratio of 1:1, and compared with adducts of Hb from animals exposed to 1 ppm 2,4-TDI vapor. Each Hb sample was subjected to C4 HPLC chain/heme separation with UV detection. Survey of the LC fractions using an antiserum prepared to a heterologous TDI-protein indicated a difference in chain specificity and product types formed in vitro by the… CONTINUE READING
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