In vivo and in vitro production of IFN-beta and IFN-gamma during graft vs host disease.


We have shown previously that high levels of IFN-beta were generated in vitro from spleen cells obtained from mice experiencing graft vs host disease (GVHD). However, very little or no IFN-gamma was found in these cultures even when IL-2 or Con A was added as a stimulant of IFN-gamma production. This study was undertaken to determine if the IFNs were… (More)


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