In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate.


BACKGROUND We previously developed 2 etomidate analogs that retain etomidate's favorable hemodynamic properties but whose adrenocortical effects are reduced in duration or magnitude. Methoxycarbonyl (MOC)-etomidate is rapidly metabolized and ultrashort acting whereas (R)-ethyl 1-(1-phenylethyl)-1H-pyrrole-2-carboxylate (carboetomidate) does not potently… (More)
DOI: 10.1213/ANE.0b013e3182320559


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