In vivo and in vitro metabolism of arylamine procarcinogens in acetyltransferase-deficient mice.

@article{Sugamori2006InVA,
  title={In vivo and in vitro metabolism of arylamine procarcinogens in acetyltransferase-deficient mice.},
  author={Kim S. Sugamori and Debbie Brenneman and Denis M. Grant},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2006},
  volume={34 10},
  pages={1697-702}
}
Arylamine N-acetyltransferases (NATs) catalyze the biotransformation of a number of aromatic and heterocyclic amines, many of which are procarcinogenic agents. Interestingly, these enzymes are binary in nature, participating in both detoxification and activation reactions, and thus it is unclear what role NATs actually play in either preventing or enhancing toxic responses. The ultimate direction may be substrate-specific and dependent on its tissue-specific metabolism by competing, but… CONTINUE READING

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