In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol

@article{Davies1999InVA,
  title={In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol},
  author={Daryl L Davies and Michael B. Bolger and Roberta Diaz Brinton and Deborah Ann Finn and Ronald L. Alkana},
  journal={Psychopharmacology},
  year={1999},
  volume={141},
  pages={339-350}
}
 The present study uses increased atmospheric pressure as an ethanol antagonist to test the hypothesis that allosteric coupling pathways in the GABAA receptor complex represent initial sites of action for ethanol. This was accomplished using behavioral and in vitro measures to determine the effects of pressure on ethanol and other GABAergic drugs in C57BL/6 and LS mice. Behaviorally, exposure to 12 times normal atmospheric pressure (ATA) of a helium-oxygen gas mixture (heliox) antagonized loss… CONTINUE READING