In vivo and in vitro hepatotoxicity and glutathione interactions of N-methyldithiocarbamate and N,N-dimethyldithiocarbamate in the rat.

  title={In vivo and in vitro hepatotoxicity and glutathione interactions of N-methyldithiocarbamate and N,N-dimethyldithiocarbamate in the rat.},
  author={Rodney W Thompson and H. Valentine and W. Valentine},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={70 2},
  • Rodney W Thompson, H. Valentine, W. Valentine
  • Published 2002
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
  • The ability of N-methyldithiocarbamate (NMDC) to generate methylisothiocyanate and HS(-) together with its greater acid stability suggest that NMDC may exert greater acute toxicity following oral exposure than its dialkyl analog,N,N-dimethyldithiocarbamate (DMDC). To assess this possibility, cell culture, perfused liver, and in vivo studies were performed to delineate differences in the hepatotoxicity and thiol interactions of NMDC and DMDC in the rat. The role of methylisothiocyanate and HS… CONTINUE READING
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