In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides.

@article{Avva1994InVA,
  title={In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides.},
  author={R R Avva and Peter Cresswell},
  journal={Immunity},
  year={1994},
  volume={1 9},
  pages={763-74}
}
HLA-DR molecules associated with class II-associated invariant chain peptides (CLIP) are generated in vivo as an intermediate in class II maturation. Such complexes can be produced in vitro by proteolytic digestion of DR alpha beta I complexes, suggesting that CLIP is a residual fragment that remains associated with class II molecules following I chain degradation. In vitro, CLIP dissociation from DR alpha beta dimers occurs at different rates depending on the allele, and is facilitated by low… CONTINUE READING