In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis.

@article{Sheng1996InVA,
  title={In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis.},
  author={Jin G. Sheng and Kanenori Ito and Robert D. Skinner and Robert E. Mrak and Cynthia R. Rovnaghi and Linda J. Van Eldik and W S T Griffin},
  journal={Neurobiology of aging},
  year={1996},
  volume={17 5},
  pages={761-6}
}
Interleukin-1 (IL-1), an inflammatory cytokine overexpressed in the neuritic plaques of Alzheimer's disease, activates astrocytes and enhances production and processing of beta-amyloid precursor protein (beta-APP). Activated astrocytes, overexpressing S100 beta, are a prominent feature of these neuritic plaques, and the neurite growth-promoting properties of S100 beta have been implicated in the formation of dystrophic neurites overexpressing beta-APP in neuritic plaques. These facts… CONTINUE READING

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