In-vivo and in-vitro evaluations of a modified-release oral dosage form of nifedipine by hybridization of hydroxypropyl-beta-cyclodextrin and hydroxypropylcelluloses in dogs.

Abstract

To maintain a suitable blood level of nifedipine for a long period of time, double-layer tablets consisting of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) and 3% nonionic surfactant (HCO-60) as a fast-release portion and hydroxypropylcelluloses (HPCs) with different viscosity grades (low, medium and high) as a slow-release portion were prepared, and… (More)

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Cite this paper

@article{Wang1994InvivoAI, title={In-vivo and in-vitro evaluations of a modified-release oral dosage form of nifedipine by hybridization of hydroxypropyl-beta-cyclodextrin and hydroxypropylcelluloses in dogs.}, author={Zhi Rong Wang and Fumitoshi Hirayama and Kaneto Uekama}, journal={The Journal of pharmacy and pharmacology}, year={1994}, volume={46 6}, pages={505-7} }