In vivo and in vitro evaluation of the acute toxicity, the genotoxicity, and the irritation potency of two hexachloroethane-based pyrotechnic smokes.

@article{Hemmil2007InVA,
  title={In vivo and in vitro evaluation of the acute toxicity, the genotoxicity, and the irritation potency of two hexachloroethane-based pyrotechnic smokes.},
  author={Matti Hemmil{\"a} and Maija Hihki{\"o} and Jukka-Pekka Kasanen and Mari K Turunen and Merja Hautam{\"a}ki and A L Pasanen and Kaija Linnainmaa},
  journal={Journal of toxicology and environmental health. Part A},
  year={2007},
  volume={70 14},
  pages={1167-81}
}
The two hexachloroethane (HC)-based smoke formulations studied consisted of HC/Zn/2,4,6-trinitrotoluene (TNT) and HC/Zn. In the in vitro tests, human bronchial epithelial cells were exposed to the smokes at various concentrations. The responses studied were acute toxicity (viability of cells, trypan blue exclusion method) and genotoxicity (DNA single-strand breaks, COMET assay). The tests were conducted in a laboratory-scale chamber (V = 150 L) and in a container (V = 55 m3). Both smoke… CONTINUE READING