In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug

@article{Grosios1999InVA,
  title={In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug},
  author={Konstantina Grosios and Susan Holwell and A. T. McGown and George R. Pettit and Michael Charles Bibby},
  journal={British Journal of Cancer},
  year={1999},
  volume={81},
  pages={1318 - 1327}
}
SummaryThe anti-tumour effects and mechanism of action of combretastatin A-4 and its prodrug, combretastatin A-4 disodium phosphate, were examined in subcutaneous and orthotopically transplanted experimental colon tumour models. Additionally, the ability of these compounds to directly interfere with endothelial cell behaviour was also examined in HUVEC cultures. Combretastatin A-4 (150 mg kg–1, intraperitoneally (i.p.)) and its water-soluble prodrug (100 mg kg–1, i.p.) caused almost complete… CONTINUE READING