Corpus ID: 201682055

In vivo and in vitro evaluation of Lu-labeled DOTA-2-deoxy-D-glucose in mice . A novel radiopharmaceutical agent for cells imaging and therapy

  title={In vivo and in vitro evaluation of Lu-labeled DOTA-2-deoxy-D-glucose in mice . A novel radiopharmaceutical agent for cells imaging and therapy},
  author={Huipan Liu and Liang Cai and Ling Zhou and Hongyuan Wei and Ying Zhong Xie},
177 Objectives: Incorporation of lutetium-177 ( Lu) into suitable molecules that are implicated in cancer pathology represents a promising approach for the diagnosis and treatment of cancer. The goal of the present 177 study was to develop a novel Lu labeled radiopharmaceutical agent for both radioimaging and targeted radionuclide therapy. Animals and Methods: Given the synthetic versatility of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) ligand as a metal chelator and high… Expand

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