In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury.

@article{Perkins2008InVA,
  title={In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury.},
  author={Gavin D Perkins and Fang Gao and David R Thickett},
  journal={Thorax},
  year={2008},
  volume={63 3},
  pages={215-20}
}
BACKGROUND Acute lung injury is an important cause of respiratory failure in the critically ill patient. It is caused by damage to the alveolar barrier with subsequent alveolar flooding leading to the development of refractory hypoxaemia. beta Agonists stimulate alveolar fluid clearance in animal models of lung injury. In a clinical trial (BALTI-1), intravenous beta agonists reduced extravascular lung water, an effect that took 72 h in contrast with what animal studies suggest. One possible… CONTINUE READING

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