In vivo and in vitro effects of peripheral galanin on nociceptive transmission in naive and neuropathic states.

@article{Flatters2003InVA,
  title={In vivo and in vitro effects of peripheral galanin on nociceptive transmission in naive and neuropathic states.},
  author={Sarah J L Flatters and Alyson J. Fox and A. H. Dickenson},
  journal={Neuroscience},
  year={2003},
  volume={116 4},
  pages={1005-12}
}
Galanin is widely distributed in the nervous system and is consistently upregulated in both dorsal root ganglion and spinal neurones by peripheral nerve injury. This study investigates the peripheral effects of galanin on nociceptive neurones using in vitro and in vivo electrophysiological techniques in naive and neuropathic rats. Using an in vitro skin-nerve preparation recording from single nociceptive fibres, galanin (1 microM) significantly inhibited firing induced by noxious heat in 65% of… CONTINUE READING