In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat.

@article{Tolle2001InVA,
  title={In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat.},
  author={Virginie Tolle and Philippe Zizzari and Catherine Tomasetto and M. C. Rio and Jacques Epelbaum and Marie Th{\'e}r{\`e}se Bluet-Pajot},
  journal={Neuroendocrinology},
  year={2001},
  volume={73 1},
  pages={54-61}
}
Ghrelin (Ghr), a 28 amino acid gastric peptide with an n-octanoylation on Ser 3, has recently been identified as an endogenous ligand of the growth hormone secretagogue (GHS) receptor. A cDNA was also isolated from a mouse stomach library encoding a protein named prepromotilin-related peptide (ppMTLRP) which shares sequence similarities with prepromotilin. Mouse and rat ppMTLRP sequences (rGhr) are identical and show 89% identity with human ghrelin (hGhr). By analogy with promotilin, cleavage… CONTINUE READING

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