In vivo and in vitro effects of magnesium sulfate in the cerebrovascular bed of the goat.

@article{Perales1991InVA,
  title={In vivo and in vitro effects of magnesium sulfate in the cerebrovascular bed of the goat.},
  author={Aurea Perales and Germ{\'a}n Torregrosa and Juan B. Salom and Francisco Javier Miranda and Jos{\'e} A Alabad{\'i} and Javier Monle{\'o}n and Enrique Alborch},
  journal={American journal of obstetrics and gynecology},
  year={1991},
  volume={165 5 Pt 1},
  pages={1534-8}
}
The effects of magnesium sulfate in the cerebrovascular bed were studied both in vivo, by measuring cerebral blood flow in conscious nonpregnant goats, and in vitro, by recording isometric tension in isolated goat middle cerebral arteries. Injections of increasing doses (10 to 300 mg) of magnesium sulfate directly into the cerebral circulation elicited transient and dose-dependent increases in cerebral blood flow and decreases in cerebral vascular resistance. Similar results were obtained when… CONTINUE READING

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