In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase.

@article{Zatta2002InVA,
  title={In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase.},
  author={Paolo Zatta and M Ibn-Lkhayat-Idrissi and Pamela Zambenedetti and Melinda Kily{\'e}n and Tibor Kiss},
  journal={Brain research bulletin},
  year={2002},
  volume={59 1},
  pages={41-5}
}
Cholinesterases are a large family of enzymatic proteins widely distributed throughout both neuronal and non-neuronal tissues. In Alzheimer's disease (AD), analytical as well as epidemiological studies suggest an implication of an abnormal focal accumulation of aluminum in the brain. In this devastating disease, aluminum may interfere with various biochemical processes including acetylcholine metabolism, and can thus act as a possible etiopathogenic cofactor. Acetylcholinesterase (AChE) exists… CONTINUE READING

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