In vivo and in vitro effects of PCB126 and PCB153 on rat testicular androgenesis.

  title={In vivo and in vitro effects of PCB126 and PCB153 on rat testicular androgenesis.},
  author={Nebojsa Andric and Tatjana Kosti{\'c} and Sonja N Kai{\vs}arevi{\'c} and Svetlana Fa and Kristina Pogrmic and Radmila Kova{\vc}evi{\'c}},
  journal={Environmental toxicology and pharmacology},
  volume={25 2},
In this study we compared the effects of PCB126 and PCB153 on adult rat testicular androgenesis and the status of antioxidant enzymes in the interstitial cell compartment 96h after local intratesticular application. Obtained results indicated PCB126-induced inhibition of conversion of progesterone (P) and Δ(4)-androstenedione (A(4)) to testosterone (T), and stimulation of conversion of P to T induced by PCB153, while combined application had no effect. Activities of antioxidant enzymes were… CONTINUE READING


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