In vivo and in vitro destruction of rat liver cytochrome P-450 by a monoterpene ketone, pulegone.

@article{Madyastha1985InVA,
  title={In vivo and in vitro destruction of rat liver cytochrome P-450 by a monoterpene ketone, pulegone.},
  author={Prema Madyastha and Bhgavatula Moorthy and Chelakard S. Vaidyanathan and K. Madhava Madyastha},
  journal={Biochemical and biophysical research communications},
  year={1985},
  volume={128 2},
  pages={921-7}
}
In vivo administration of pulegone once daily decreased the levels of liver microsomal cyt. P-450 to the extent of 32 and 76% at the end of 24 and 96 hrs respectively. However, cyt. b5 and NAD(P)H-cyt. c reductase activities remained unchanged. In vitro incubation (15 min) of liver microsomes from phenobarbitol (PB)-treated rats with pulegone (10 mM), aerobically or anaerobically resulted in the loss (approximately 60%) of cyt. P-450 in the presence or absence of NADPH. Destruction of cyt. P… CONTINUE READING

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