In vivo and in vitro bi-exponential diffusion of N-acetyl aspartate (NAA) in rat brain: a potential structural probe?

  title={In vivo and in vitro bi-exponential diffusion of N-acetyl aspartate (NAA) in rat brain: a potential structural probe?},
  author={Yaniv Assaf and Yoram Cohen},
  journal={NMR in biomedicine},
  volume={11 2},
Diffusion measurements were performed on the N-acetyl aspartate (NAA) signal in in situ brains (in vivo and post-mortem) and on in vitro brain tissue at 37 degrees C using wide ranges of b-values (from 0 up to 4.5 x 10(6) s/cm2 and 35.8 x 10(6) s/cm2 for the in vivo and the in vitro cases, respectively). In vivo and in vitro NAA signals attenuation due to diffusion was measured at fixed diffusion times (tD). In the in vitro cases the effect of tD on the apparent diffusion coefficients (ADCs) of… CONTINUE READING


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