In vivo analysis of the model tyrosine aminotransferase gene reveals multiple sequential steps in glucocorticoid receptor action

@article{Grange2001InVA,
  title={In vivo analysis of the model tyrosine aminotransferase gene reveals multiple sequential steps in glucocorticoid receptor action},
  author={Thierry Grange and Lucia Cappabianca and Mich{\`e}le Flavin and Habib Sassi and H{\'e}l{\`e}ne Thomassin},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={3028-3038}
}
We are studying the mechanisms of transcriptional activation by nuclear receptors and we focus our studies on the glucocorticoid regulation of the model tyrosine aminotransferase gene. Rather than using in vitro biochemical approaches, we determine the actual events occurring in the cells. Our experimental approaches include genomic footprinting, chromatin immunoprecipitation, in situ hybridization and transgenic mice. Our results show that the glucocorticoid receptor uses a dynamic multistep… CONTINUE READING

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