In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

@article{Ahn2005InVA,
  title={In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog},
  author={Sohyun Ahn and Alexandra L. Joyner},
  journal={Nature},
  year={2005},
  volume={437},
  pages={894-897}
}
Sonic hedgehog (Shh) has been implicated in the ongoing neurogenesis in postnatal rodent brains. Here we adopted an in vivo genetic fate-mapping strategy, using Gli1 (GLI-Kruppel family member) as a sensitive readout of Shh activity, to systematically mark and follow the fate of Shh-responding cells in the adult mouse forebrain. We show that initially, only a small population of cells (including both quiescent neural stem cells and transit-amplifying cells) responds to Shh in regions undergoing… Expand
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