In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.

@article{Takaishi2011InVA,
  title={In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.},
  author={Shigeo Takaishi and Wataru Shibata and Hiroyuki Tomita and Guangchun Jin and Xiangdong Yang and Russell Erick Ericksen and Zinaida A Dubeykovskaya and Samuel G. Asfaha and Michael Quante and Kelly S. Betz and Arthur Shulkes and Timothy C Wang},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2011},
  volume={300 2},
  pages={G334-44}
}
Gastrin is secreted from a subset of neuroendocrine cells residing in the gastric antrum known as G cells, but low levels are also expressed in fetal pancreas and intestine and in many solid malignancies. Although past studies have suggested that antral gastrin is transcriptionally regulated by inflammation, gastric pH, somatostatin, and neoplastic transformation, the transcriptional regulation of gastrin has not previously been demonstrated in vivo. Here, we describe the creation of an… CONTINUE READING

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