In vivo analysis of aquaporin 0 function in zebrafish: permeability regulation is required for lens transparency.

@article{Clemens2013InVA,
  title={In vivo analysis of aquaporin 0 function in zebrafish: permeability regulation is required for lens transparency.},
  author={Daniel M. Clemens and Karin L. N{\'e}meth-Cahalan and Lien Thi Minh Trinh and Tailin Zhang and Thomas F Schilling and James Edwin Hall},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 7},
  pages={5136-43}
}
PURPOSE The zebrafish lens is well suited for studies of physiology and development due to its rapid formation in the embryo and genetic accessibility. Aquaporin 0 (AQP0), a lens-specific membrane protein, is required for lens clarity. Zebrafish have two copies of AQP0 (Aqp0a and b), whereas mammals have a single, multifunctional protein. Here we demonstrate a reliable knockdown/rescue system in zebrafish and use it to provide evidence for subfunctionalization of Aqp0a and b, as well as to show… CONTINUE READING
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