In vivo analysis of Fas/FasL interactions in HIV-infected patients.

  title={In vivo analysis of Fas/FasL interactions in HIV-infected patients.},
  author={Andrew D Badley and David H Dockrell and Alicia Algeciras and Steven C. Ziesmer and Alan L. Landay and Michael M. Lederman and Elizabeth Connick and Harold Kessler and Daniel R. Kuritzkes and David H. Lynch and Patrick C. Roche and H. Yagita and Carlos V. Paya},
  journal={The Journal of clinical investigation},
  volume={102 1},
Recent insights into the pharmacological control of HIV replication and the molecular mechanisms of peripheral T cells homeostasis allowed us to investigate in vivo the mechanisms mediating T cell depletion in HIV-infected patients. Before the initiation of highly active antiretroviral therapy (HAART), a high degree of lymphoid tissue apoptosis is present, which is reduced upon HAART initiation (P < 0.001) and directly correlates with reduction of viral load and increases of peripheral T… CONTINUE READING


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The expression of Fas ligand by differentiated macrophages and its upregulation by HIV infection

  • D. H. Dockrell, A. D. Badley, +6 authors C. V. Paya
  • J. Clin. Invest
  • 1998
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