In vivo administration of recombinant growth hormone or gamma interferon activities macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with generation of reactive oxygen intermediates.

@article{Edwards1992InVA,
  title={In vivo administration of recombinant growth hormone or gamma interferon activities macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with generation of reactive oxygen intermediates.},
  author={Carl Keith Edwards and S M Ghiasuddin and Libby M. Yunger and Robert M. Lorence and Se{\'a}n Arkins and Robert Dantzer and Keith W. Kelley},
  journal={Infection and immunity},
  year={1992},
  volume={60 6},
  pages={2514-21}
}
Purified and recombinant forms of growth hormone (GH) as well as of recombinant rat gamma interferon (IFN-gamma) enhance the survival of rats deprived of endogenous pituitary GH secretion by hypophysectomy (HX rats) and infected with virulent Salmonella typhimurium. Macrophages obtained from rats with intact pituitaries (pituitary-intact rats) or HX rats that were treated in vivo with either GH or the closely related hormone prolactin released elevated (P less than 0.05) levels of superoxide… CONTINUE READING

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Further studies on the fractionation of human pituitary glands

  • E. Pick
  • Endocrinology
  • 1965

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