In vivo administration of CD4-specific monoclonal antibody: effect on provirus load in rhesus monkeys chronically infected with the simian immunodeficiency virus of macaques.

@article{Reimann1995InVA,
  title={In vivo administration of CD4-specific monoclonal antibody: effect on provirus load in rhesus monkeys chronically infected with the simian immunodeficiency virus of macaques.},
  author={Keith A Reimann and Richard L. Cate and Yin-wei Wu and Lesley Palmer and Dian Olson and B. C. D. Waite and Norman L. Letvin and Linda Burkly},
  journal={AIDS research and human retroviruses},
  year={1995},
  volume={11 4},
  pages={517-25}
}
Since monoclonal antibodies (MAb) specific for CD4 are potent inhibitors of HIV and SIV replication in vitro, we explored their potential usefulness in vivo as an AIDS therapy. The anti-CD4 MAb 5A8 binds to domain 2 of the CD4 molecule and inhibits virus replication and virus-induced cell fusion at a postvirus binding step. Administration of this MAb to normal rhesus monkeys coats all circulating and lymph node CD4 cells and induces neither CD4 cell clearance nor measurable immunosuppression… CONTINUE READING

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