In vivo adenovirus-mediated gene transduction into mouse endometrial glands: a novel tool to model endometrial cancer in the mouse.

@article{Beauparlant2004InVA,
  title={In vivo adenovirus-mediated gene transduction into mouse endometrial glands: a novel tool to model endometrial cancer in the mouse.},
  author={S. Beauparlant and P. Read and A. Di Cristofano},
  journal={Gynecologic oncology},
  year={2004},
  volume={94 3},
  pages={
          713-8
        }
}
  • S. Beauparlant, P. Read, A. Di Cristofano
  • Published 2004
  • Biology, Medicine
  • Gynecologic oncology
  • OBJECTIVE The lack of an endometrial epithelium-specific promoter has slowed down the development of technically advanced mouse models of endometrial cancer. The aim of this study was to test whether direct in vivo adenoviral-mediated gene delivery can be used to circumvent this problem. METHODS Adenoviruses expressing the LacZ reporter gene or the Cre recombinase were injected into the left horn of the mouse uterus. Histochemistry and immunohistochemistry were used to detect expression of… CONTINUE READING
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    References

    SHOWING 1-10 OF 26 REFERENCES
    Development of novel formulations that enhance adenoviral-mediated gene expression in the lung in vitro and in vivo.
    • 38
    In-vivo transfection of the female reproductive tract epithelium.
    • 25
    • PDF
    Conditional mouse models of sporadic cancer
    • 278
    • PDF
    MUC1 and other sialoglycoconjugates inhibit adenovirus-mediated gene transfer to epithelial cells.
    • 90
    • PDF