In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation.

@article{Billet1995InVA,
  title={In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation.},
  author={Olivier Billet and Gis{\`e}le Grimber and Massimo Levrero and K A Seye and Pascale Briand and Virginie Joulin},
  journal={Journal of virology},
  year={1995},
  volume={69 9},
  pages={5912-6}
}
The contribution of the hepatitis B virus enhancers I and II in the regulation of the activity of the core and the X promoters was assessed in transgenic mice. Surprisingly, despite the presence of heterologous promoters linked 5' of the X gene, the transgene expression is mostly due to core promoter (Cp) activity present in the X coding sequence. Moreover, the restriction of Cp activity to hepatic tissue required the combined action of both enhancers I and II, whereas the proximity of these… CONTINUE READING

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