In vivo activity of CRISPR‐mediated virus defence in a hyperthermophilic archaeon

@article{Manica2011InVA,
  title={In vivo activity of CRISPR‐mediated virus defence in a hyperthermophilic archaeon},
  author={A. Manica and Ziga Zebec and D. Teichmann and C. Schleper},
  journal={Molecular Microbiology},
  year={2011},
  volume={80}
}
Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas systems are found widespread in bacterial and archaeal genomes and exhibit considerable diversity. However, closer insights into the action of most of the CRISPR modules have remained elusive in particular in Archaea as a result of the lack of suitable in vivo test systems. Here we demonstrate CRISPR/Cas‐based immune defence in the hyperthermophilic archaeon Sulfolobus solfataricus. Recombinant variants of the SSV1 virus… Expand
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