In vivo activities of novel benzoxazinorifamycins against Mycobacterium leprae.

@article{Dhople1995InVA,
  title={In vivo activities of novel benzoxazinorifamycins against Mycobacterium leprae.},
  author={Arvind M. Dhople and M A Ib{\'a}{\~n}ez},
  journal={Indian journal of leprosy},
  year={1995},
  volume={67 4},
  pages={375-82}
}
Among the four newly synthesized benzoxazinorifamycin derivatives, KRM-1648 and KRM-2312 completely inhibited the multiplication of rifampicin-sensitive as well as rifampicin-resistant strains of M. leprae in the foot-pads of mice. Both were found to be more potent than rifampicin and were bactericidal. In combination with ofloxacin, another potent… CONTINUE READING