In vivo absence of synergism between fibroblast growth factor-2 and vascular endothelial growth factor.

@article{Nico2001InVA,
  title={In vivo absence of synergism between fibroblast growth factor-2 and vascular endothelial growth factor.},
  author={B Nico and Giulia De Falco and Angelo Vacca and Luisa Roncali and Domenico Ribatti},
  journal={Journal of hematotherapy & stem cell research},
  year={2001},
  volume={10 6},
  pages={905-12}
}
Fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) are potent angiogenesis inducers in vivo and in vitro and may act in synergy. This possibility has been investigated by their simultaneous administration in the chick embryo chorioallantoic membrane (CAM) assay. Macroscopic and microscopic quantification of the angiogenic response 4 days after administration clearly demonstrated the absence of synergism. When FGF-2 or VEGF concentration was fixed at 0.25 microg… CONTINUE READING

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