In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor.

@article{Newell1991InVT,
  title={In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor.},
  author={Kenneth A. Newell and Joshua D. I. Ellenhorn and David S Bruce and Jeffrey A Bluestone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 3},
  pages={1074-8}
}
Treatment of T cells with staphylococcal enterotoxins in vitro is known to activate T cells in a subset restricted manner based on beta-chain variable region (V beta) gene expression. In particular, staphylococcal enterotoxin B (SEB) activates T cells bearing V beta 7 or V beta 8. We examined the ability of SEB to activate T cells in vivo. Treatment of C3H mice with doses of SEB ranging from 5 to 250 micrograms resulted in a dose-dependent activation of V beta 8+ T cells as reflected by… CONTINUE READING

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