Corpus ID: 3107255

In vivo Significance of the G 2 Restriction Point

@inproceedings{Foijer2007InVS,
  title={In vivo Significance of the G 2 Restriction Point},
  author={F. Foijer and Elly Delzenne-Goette and M. Dekker and H. Riele},
  year={2007}
}
  • F. Foijer, Elly Delzenne-Goette, +1 author H. Riele
  • Published 2007
  • Loss of activity of the retinoblastoma pathway is a common event in human cancer. Mouse models have revealed that tumorigenesis by loss of Rb was accelerated by concomitant loss of the cell cycle inhibitor p27 . This has been attributed to reduced apoptosis and weakening of the G1 checkpoint. However, the role of p27 in a recently identified G2 restriction point may offer an alternative explanation for this synergy. Here, we have investigated the significance of the G2 restriction point in Rb… CONTINUE READING
    1 Citations

    Figures and Tables from this paper.

    References

    SHOWING 1-10 OF 27 REFERENCES
    Mitogen requirement for cell cycle progression in the absence of pocket protein activity.
    • 56
    • PDF
    Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization.
    • 590
    • PDF
    p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
    • 156
    • PDF
    The Rb/E2F pathway: expanding roles and emerging paradigms.
    • 1,100
    • PDF
    Deregulated degradation of the cdk inhibitor p27 and malignant transformation.
    • 371
    • PDF
    Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.
    • 148
    • PDF
    Skp2-mediated degradation of p27 regulates progression into mitosis.
    • 325
    Mice Lacking p27Kip1 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors
    • 1,588