Corpus ID: 3107255

In vivo Significance of the G 2 Restriction Point

  title={In vivo Significance of the G 2 Restriction Point},
  author={F. Foijer and Elly Delzenne-Goette and M. Dekker and H. Riele},
  • F. Foijer, Elly Delzenne-Goette, +1 author H. Riele
  • Published 2007
  • Loss of activity of the retinoblastoma pathway is a common event in human cancer. Mouse models have revealed that tumorigenesis by loss of Rb was accelerated by concomitant loss of the cell cycle inhibitor p27 . This has been attributed to reduced apoptosis and weakening of the G1 checkpoint. However, the role of p27 in a recently identified G2 restriction point may offer an alternative explanation for this synergy. Here, we have investigated the significance of the G2 restriction point in Rb… CONTINUE READING
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