In vivo Serotonin release and learned helplessness

@article{Petty1994InVS,
  title={In vivo Serotonin release and learned helplessness},
  author={Frederick Curtis Petty and Gerald L. Kramer and Leann Wilson and Shaun N. Jordan},
  journal={Psychiatry Research},
  year={1994},
  volume={52},
  pages={285-293}
}
Learned helplessness, a behavioral depression caused by exposure to inescapable stress, is considered to be an animal model of human depressive disorder. Like human depression, learned helplessness has been associated with a defect in serotonergic function, but the nature of this relationship is not entirely clear. We have used in vivo microdialysis brain perfusion to measure serotonin (5-hydroxytryptamine, 5HT) in extracellular space of medial frontal cortex in conscious, freely moving rats… CONTINUE READING
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