In vivo RNAi: today and tomorrow.

@article{Perrimon2010InVR,
  title={In vivo RNAi: today and tomorrow.},
  author={Norbert Perrimon and Jian-Quan Ni and Lizabeth Perkins},
  journal={Cold Spring Harbor perspectives in biology},
  year={2010},
  volume={2 8},
  pages={
          a003640
        }
}
RNA interference (RNAi) provides a powerful reverse genetics approach to analyze gene functions both in tissue culture and in vivo. Because of its widespread applicability and effectiveness it has become an essential part of the tool box kits of model organisms such as Caenorhabditis elegans, Drosophila, and the mouse. In addition, the use of RNAi in animals in which genetic tools are either poorly developed or nonexistent enables a myriad of fundamental questions to be asked. Here, we review… CONTINUE READING

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