In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes

Abstract

Type 1 diabetes is an autoimmune disease influenced by multiple genetic loci. Although more than 20 insulin-dependent diabetes (Idd) loci have been implicated in the nonobese diabetic (NOD) mouse model, few causal gene variants have been identified. Here we show that RNA interference (RNAi) can be used to probe candidate genes in this disease model. Slc11a1… (More)
DOI: 10.1038/ng1766

3 Figures and Tables

Topics

  • Presentations referencing similar topics