In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4-negative DRG neurons.

@article{Fjell1999InVN,
  title={In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4-negative DRG neurons.},
  author={J Fjell and Theodore R. Cummins and Katalin Fried and J Andrew Black and Stephen G. Waxman},
  journal={Journal of neurophysiology},
  year={1999},
  volume={81 2},
  pages={803-10}
}
Recent evidence suggests that changes in sodium channel expression and localization may be involved in some pathological pain syndromes. SNS, a tetrodotoxin-resistant (TTX-R) sodium channel, is preferentially expressed in small dorsal root ganglion (DRG) neurons, many of which are nociceptive. TTX-R sodium currents and SNS mRNA expression have been shown to be modulated by nerve growth factor (NGF) in vitro and in vivo. To determine whether SNS expression and TTX-R currents in DRG neurons are… CONTINUE READING