In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses.

@article{Dongre2001InVM,
  title={In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses.},
  author={Ashok R. Dongre and Susan Kovats and Paul deRoos and Ashley L. McCormack and Terry Y. Nakagawa and Vladislava Paharkova-Vatchkova and Jimmy Eng and Hd Caldwell and John R. Yates and Alexander Yu Rudensky},
  journal={European journal of immunology},
  year={2001},
  volume={31 5},
  pages={
          1485-94
        }
}
We report a strategy for high through-put sequence analyses of large MHC class II-bound peptide repertoires which combines automated electrospray ionization tandem mass-spectrometry with computer-assisted interpretation of the tandem mass spectra using the algorithm SEQUEST. This powerful approach discerned 128 peptide sequences displayed by the murine MHC class II molecule I-Ab in activated B cells and macrophages, including a surprisingly large number of peptides derived from self cytosolic… CONTINUE READING
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