In vivo Identification and Specificity assessment of mRNA markers of hypoxia in human and mouse tumors

@inproceedings{Busk2010InVI,
  title={In vivo Identification and Specificity assessment of mRNA markers of hypoxia in human and mouse tumors},
  author={Morten Busk and Kasper Toustrup and Brita Singers S\orensen and Jan Alsner and Michael Robert Horsman and Steen S Jakobsen and Jens Overgaard},
  booktitle={BMC Cancer},
  year={2010}
}
Tumor hypoxia is linked to poor prognosis, but identification and quantification of tissue hypoxia remains a challenge. The hypoxia-specificity of HIF-1α target genes in vivo has been questioned due to the confounding influence of other microenvironmental abnormalities known to affect gene expression (e.g., low pH). Here we describe a new technique that by exploiting intratumoral oxygenation heterogeneity allows us to identify and objectively rank the most robust mRNA hypoxia biomarkers. Mice… CONTINUE READING