In vivo EVALUATION OF PHOTOPROTECTION AGAINST CHRONIC ULTRAVIOLET‐A IRRADIATION BY A NEW SUNSCREEN MEXORYL® SX *

@article{Fourtanier1992InVE,
  title={In vivo EVALUATION OF PHOTOPROTECTION AGAINST CHRONIC ULTRAVIOLET‐A IRRADIATION BY A NEW SUNSCREEN MEXORYL{\textregistered} SX *},
  author={Anny Fourtanier and Jacqueline Labat-Robert and Patrick Kern and Claudine Berrebi and A M Gracia and B Boyer},
  journal={Photochemistry and Photobiology},
  year={1992},
  volume={55}
}
Abstract— In a previous study on the hairless mouse it was shown that sub‐erythemal doses of pure UV‐A enhanced the numerous changes normally observed during chronological aging. A new sunscreen (a bis‐benzylidene campho sulfonic acid derivative) has been synthesized in our research laboratory (Λmax: 345 nm, ε: 47000). Its photoprotective properties against UV‐A induced damages were assessed in our mouse model. Three month old albino hairless mice were exposed for 1 y to suberythemal doses (35… 
Evaluation of the Protective Effect of Sunscreens on In Vitro Reconstructed Human Skin Exposed to UVB or UVA Irradiation
TLDR
The evaluation of photoprotection on in vitro reconstructed skin revealed good efficiency for both preparations in preventing UVB‐induced damage, as shown by SBC counting and pyrimidine dimer immunostaining, and only the Mexoryl® SX‐containing preparation was able to efficiently prevent UVA‐specific damage such as dermal fibroblast disappearance.
Evaluation of the Protective Effect of Sunscreens on In Vitro Reconstructed Human Skin Exposed to UVB or UVA Irradiation
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The partial efficacy of the topical photoprotection from UVA by the sunscreen in inhibiting elastase activation is suggested, and the possibility of reducing photoaging is suggested.
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The involvement of UVA (fibroblast alteration, increased metalloproteinase expression) and the pivotal need for well‐balanced UVA/UVB sunscreens were further demonstrated using reconstructed three‐dimensional skin models.
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Broad-spectrum sunscreens with UVA I and UVA II absorbers provide increased protection against solar-simulating radiation-induced dermal damage in hairless mice
TLDR
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Carcinogenesis induced by UVA (365-nm) radiation: the dose-time dependence of tumor formation in hairless mice
TLDR
The dose-time relationship for skin tumor induction in hairless mice that were irradiated daily with custom-made Philips 365-nm sources was determined and it was found that the carcinogenicity at 365 nm (per J/m2) is 0.9 x 10(-4) times that at 293 nm, the wavelength of maximum carcinogensicity inhairless mice.
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References

SHOWING 1-10 OF 68 REFERENCES
Sunscreens with low sun protection factor inhibit ultraviolet B and A photoaging in the skin of the hairless albino mouse.
TLDR
The data suggest that UVA may be important in photoaging and that the use of low sun protection factor UVB+ UVA sunscreens on a day-to-day basis may offer some protection from solar photoaging.
WAVELENGTH DEPENDENCE OF HISTOLOGICAL, PHYSICAL, AND VISIBLE CHANGES IN CHRONICALLY UV‐IRRADIATED HAIRLESS MOUSE SKIN *
TLDR
The wavelength dependence spectra indicate that for all but one parameter measured (skin sagging), UV‐B radiation is considerably more efficient than UV‐A radiation in producing changes in the skin, and argues in favor of using broad spectrum photoprotective agents to shield the skin adequately from UV‐induced aging.
The Effects of Uva Radiation: Are Sunscreens Protective Enough?
AbstractIn previous studies with albino hairless mice, we showed that broadband ultraviolet A radiation (UVA) damages dermal connective tissue. Recent studies examined segments of the UVA waveband in
BIOCHEMICAL CHANGES IN HAIRLESS MOUSE SKIN COLLAGEN AFTER CHRONIC EXPOSURE TO ULTRAVIOLET‐A RADIATION *
TLDR
It is suggested that chronic UV‐A radiation may increase cross‐linking of dermal collagen in Albino hairless mice by increasing the dose response at 4000 and 8000 J/cm2 as delivered by the UVASUN.
AN ANIMAL MODEL OF SOLAR‐AGED SKIN: HISTOLOGICAL, PHYSICAL, and VISIBLE CHANGES IN UV‐IRRADIATED HAIRLESS MOUSE SKIN *
TLDR
The effects with UVA irradiation were like those observed in mouse chronological aging, and the convenient physical and visible grading methods described can be used to determine the effectiveness of topical treatments, such as sunscreens.
Ultraviolet radiation-induced connective tissue changes in the skin of hairless mice.
TLDR
The results indicate that definitive changes in the biochemistry of dermal connective tissues can be induced by exposure of mice to UV irradiation.
UVB-induced collagen changes in the skin of the hairless albino mouse.
TLDR
Previous human studies, which showed an increase in type III collagen in sun-exposed skin when compared with covered sites, showed that in irradiated mice withdrawn from UV exposure the ratio D/V III tended to revert to control levels.
The contributions of UVA and UVB to connective tissue damage in hairless mice.
TLDR
Like UVB, the UVA waveband, especially that with a spectral distribution similar to solar UVA, caused elastic fiber damage, increased glycosaminoglycan levels, and produced hypertrophy of deep dermal tissues and substantial protection was afforded by a broad-spectrum sunscreen.
The interaction of UVA and UVB in the production of threshold erythema.
TLDR
It was demonstrated that when UVA was followed by UVB an erythema was produced in those sites where the sum of the fractions was equal to one, an interaction termed photoaddition, which is suggestive of photorecovery.
COMPARISON OF THE ERYTHEMOGENIC EFFECTIVENESS OF ULTRA VIOLET‐B (290‐320 nm) and ULTRA VIOLET‐A (320‐400 nm) RADIATION BY SKIN REFLECTANCE
TLDR
UVA and UVB fluences that cause cutaneous blood in the superficial plexus to increase to 1.5, 2 and 2.5 times the pre‐radiation volume at various times after irradiation show that on an equal fluence basis, UVB is two to three thousand times as effective as UVA in inducing erythema, whether ery thema is evaluated 8, 24 or 72 h after irradiated.
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