In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases

@inproceedings{BonnehBarkay2010InVC,
  title={In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases},
  author={Dafna Bonneh-Barkay and Guoji Wang and Adam Starkey and Ronald L. Hamilton and Clayton A Wiley},
  booktitle={Journal of Neuroinflammation},
  year={2010}
}
CHI3L1 (YKL-40) is up-regulated in a variety of inflammatory conditions and cancers. We have previously reported elevated CHI3L1 concentration in the cerebrospinal fluid (CSF) of human and non-human primates with lentiviral encephalitis and using immunohistochemistry showed that CHI3L1 was associated with astrocytes. In the current study CHI3L1 transcription and expression were evaluated in a variety of acute and chronic human neurological diseases. ELISA revealed significant elevation of… CONTINUE READING