In vivo 3D MRI staining of the mouse hippocampal system using intracerebral injection of MnCl2.

@article{Watanabe2004InV3,
  title={In vivo 3D MRI staining of the mouse hippocampal system using intracerebral injection of MnCl2.},
  author={Takashi Watanabe and Jelena Radulovic and Joachim Spiess and Oliver Natt and Susann Boretius and Jens Frahm and Thomas Michaelis},
  journal={NeuroImage},
  year={2004},
  volume={22 2},
  pages={860-7}
}
The morphology and function of the hippocampal system of C57BL/6J mice (n = 8) was studied in vivo using T1-weighted 3D magnetic resonance imaging (MRI) (117 microm isotropic resolution) after bilateral injection of MnCl(2) (0.25 microl, 5 or 200 mM) into the posterior hippocampal formation. The neuronal uptake of the T1-shortening Mn(2+) ions resulted in a pronounced MRI signal enhancement within the CA3 subfield and dentate gyrus with milder increases in CA1 and subiculum. This finding is in… CONTINUE READING
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