In vivo 13C magnetic resonance spectroscopy of a human brain tumor after application of 13C-1-enriched glucose.

@article{Wijnen2010InV1,
  title={In vivo 13C magnetic resonance spectroscopy of a human brain tumor after application of 13C-1-enriched glucose.},
  author={Jannie P Wijnen and Marinette van der Graaf and Tom W. J. Scheenen and Dennis W. J. Klomp and Bastiaan E. de Galan and Albert J. Idema and Arend Heerschap},
  journal={Magnetic resonance imaging},
  year={2010},
  volume={28 5},
  pages={
          690-7
        }
}

• Jannie P Wijnen, Marinette van der Graaf, +4 authors Arend Heerschap
• Published 2010 in Magnetic resonance imaging
• DOI:10.1016/j.mri.2010.03.006

OBJECTIVES As a unique tool to assess metabolic fluxes noninvasively, (13)C magnetic resonance spectroscopy (MRS) could help to characterize and understand malignancy in human tumors. However, its low sensitivity has hampered applications in patients. The aim of this study was to demonstrate that with sensitivity-optimized localized (13)C MRS and intravenous infusion of [1-(13)C]glucose under euglycemia, it is possible to assess the dynamic conversion of glucose into its metabolic products in… CONTINUE READING

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