In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol

@article{Tauscher1999InV1,
  title={In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol},
  author={Johannes A Tauscher and Bernd K{\"u}fferle and Susanne Asenbaum and Petra Fischer and Lukas Pezawas and Christian Barnas and Sitra Tauscher-Wisniewski and Thomas Bruecke and Siegfried Kasper},
  journal={Psychopharmacology},
  year={1999},
  volume={141},
  pages={175-181}
}
We investigated the degree of striatal dopamine-2 (D2) receptor occupancy in six schizophrenic patients receiving clinically effective antipsychotic treatment with olanzapine 10–25 mg/day in comparison to patients treated with clozapine 300–600 mg/day (n = 6) or haloperidol 5–20 mg/day (n = 10). 123I Iodobenzamide (IBZM) and single photon emission computerized tomography (SPECT) were used for the visualization of striatal D2 receptors. For the quantification of striatal D2 receptor occupancy… CONTINUE READING

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